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scientific studies have revealed that MAO-B inhibitors can improve the functionality of brain mitochondria by inhibiting the action of nitric oxide synthase and decreasing the manufacture of hydrogen peroxide [forty three]. Furthermore, MAO-B inhibitors can regulate membrane permeability changes in mitochondria a result of neurotoxins and oxidative

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JE developed and carried out experiments, analyzed data and wrote the manuscript. BTL and AB performed experiments and analyzed information. ALC, CR and AB assisted style and design and accomplish in vivo mouse scientific studies. AK, MRM, CELN and SA participated in experimental layout and facts Assessment. SS and MK designed the KPT-330 compound

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